Regulation of obesity, heart function, and lifespan by the nutrient sensing TOR pathway
نویسندگان
چکیده
منابع مشابه
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we exam...
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Supplemental Experimental Procedures Flies were raised on standard laboratory food at 25 C, and weights of 3to 5-day-old male flies were measured in four replicates of ten Drosophila Strains da-Gal4, 24B-GAL4, appl-GAL4, and gmr-GAL4 strains were obflies by using a Sartorius fine balance (Sartorius Genius Series, model ME). tained from the Drosophila stock center (Bloomington, Indiana). PO188-G...
متن کاملThe tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
The Tor pathway mediates cell growth in response to nutrient availability, in part by inducing ribosomal protein (RP) gene expression via an unknown mechanism. Expression of RP genes coincides with recruitment of the Esa1 histone acetylase to RP gene promoters. We show that inhibition of Tor with rapamycin releases Esa1 from RP gene promoters and leads to histone H4 deacetylation without affect...
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High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular disease, but the underlying genetic mechanisms are poorly understood. Here, we use Drosophila to test the hypothesis that HFD-induced obesity and associated cardiac complications have early evolutionary origins involving nutrient-sensing signal transduction pathways. We find that HFD-fed flies exhibit incr...
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G protein-coupled receptors (GPCRs) are critical for cardiovascular physiology. Cardiac cells express >100 nonchemosensory GPCRs, indicating that important physiological and potential therapeutic targets remain to be discovered. Moreover, there is a growing appreciation that members of the large, distinct taste and odorant GPCR families have specific functions in tissues beyond the oronasal cav...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.93.1